Globally acclaimed vampire hunter, Professor Bartholomew Dubbs, is hosting a weekend seminar at his Vampire Slaying Institute, focusing on techniques to locate and eliminate vampires. Unbeknownst to him, his class has been infiltrated by vampires, including their coven leader, Camelia Bumbescu, who plans to assassinate Dubbs during the red moon as revenge for her lover’s death 300 years ago at the hands of Dubbs’ ancestor, Gunter Dubbs. The professor is aided by three assistants, led by Samantha Wilson, but they face a daunting challenge against this peculiar group of misfit vampires.