A group of fortunate lottery winners find themselves on what appears to be a perfect island getaway. However, the paradise quickly turns into a nightmare as guests begin to vanish mysteriously, one after another. The trouble begins when the electric barrier, which separates the island’s wildlife from its human visitors, starts to fail. Myra, a journalist specializing in entertainment, discovers the grim truth: they are stranded on an island overrun by lethal and ravenous pythons. With no means of communication to call for help, their only escape is a passenger boat expected to arrive in three days.