After a tough breakup, Jessie decides to buy a sheet of acid to share with his friends back in Missouri, hoping it will help him forget the painful moment when his college girlfriend broke up with him during sex. Leaving New Orleans, he opts for a scenic drive along Route 61 to escape the dullness of the Interstate. However, his car breaks down at an overlooked trailer park in Cleveland, Mississippi. Fearing for his safety among a group of bikers, Jessie trades hits of L.S.D. for a safe journey back home. Throughout the day, he finds the extraordinary in the ordinary and breathes new life into the stories of many. This tale is inspired by a real-life misadventure.