To everyone else, Wilfred appears to be nothing more than a dog, but to Ryan, he is a brash and slightly grumpy, yet undeniably courageous and sincere Australian guy dressed in a shabby dog costume. As they embark on a variety of humorous and thought-provoking escapades, Wilfred the dog guides Ryan in confronting his anxieties and wholeheartedly accepting the chaos and unpredictability of life.