In this gripping thriller, we follow Dr. Ephraim Goodweather, who leads the Canary Team at the Center for Disease Control in New York City. He and his team are tasked with examining a puzzling viral outbreak that bears the characteristics of an ancient and malevolent form of vampirism. As the infection proliferates, Eph, his team, and a group of ordinary New Yorkers join forces to battle for the survival of humanity.