The dynamic between detective Jane Rizzoli and medical examiner Maura Isles is likely so successful due to their contrasting personalities. Jane, the sole woman in Boston’s homicide unit, is tenacious and unyielding, seldom lowering her defenses. In contrast, Maura, always impeccably dressed, can come across as aloof, feeling more at ease with the deceased than the living. Despite these differences, the two have developed an unusual yet supportive friendship, allowing them to be vulnerable with one another. Together, they pool their skills to tackle Boston’s most challenging cases.