Raizel emerges from an 820-year-long sleep, bearing the distinguished title of Noblesse, signifying his status as a pure-blooded Noble and guardian of his kind. To shield Raizel, his loyal servant Frankenstein enrolls him at Ye-Ran High School, where Raizel starts to understand the ordinary and everyday aspects of human life through interactions with his classmates.

Meanwhile, the Union—a powerful clandestine organization with global influence and ambitions of world domination—sends enhanced humans to infiltrate Raizel’s life. This forces him to unleash his formidable powers to defend those around him.

After centuries of mystery, the truth behind his prolonged slumber is unveiled, marking the beginning of Raizel’s role as the ultimate protector in his capacity as the Noblesse.