William Masters and Virginia Johnson were trailblazers in the study of human sexuality. Their groundbreaking work ignited the sexual revolution, propelling them from a teaching hospital in the Midwest to the cover of Time magazine and frequent guest spots on Johnny Carson’s show. Masters, a gifted scientist, struggles with his own emotions, while Johnson, a single mother, is a progressive figure for her era. The series explores their extraordinary lives, romantic relationship, and unexpected rise to pop culture fame.