As the final evening of work looms for the staff at a mental institution, a skeleton crew of security personnel and researchers remains to monitor the patients’ behavior before their transfer to a high-security prison. Dr. Helen Kingford, grappling with feelings of abandonment, is on the verge of resigning from her role as a psychologist. Meanwhile, the head of security, facing mandatory retirement, embarks on a reckless plan that plunges the asylum into chaos and destruction. Amidst the turmoil, the dangerous patients break free from their padded cells. Dr. Kingford regains consciousness to find herself bound in the hospital morgue. Unsure of whom to trust, she is forced to flee from everyone in a desperate bid for survival.