When brothers Josh and Mike head to a quaint southern town for a getaway, they discover that many of the locals are either dead or have vanished. After Mike disappears, Josh joins forces with the town’s sheriff and a charming schoolteacher to search for him. During their investigation, Josh uncovers a horrifying truth: the entire town and its inhabitants have been contaminated by toxic waste, transforming them into toxic vampires who roam the streets at night in search of human blood.