Rex is sent on a mission to lower Manhattan, where an E.V.O.-infected human named Peter Meechum which infects everything it touches is turning humans into zombies. Rex wants to attempt a cure, but White Knight is determined to prevent the infection from spreading, and is willing to resort to destroying the city with a nuclear bomb. Complicating the matter further, Peter is being blackmailed by Van Kleiss (who has Biowulf kidnap his daughter) and refuses the cure. Rex and Agent Six must cooperate to save the girl from the Pack and the city from the bomb, all behind White Knight’s back.