Jack Ford heads a special operations team returning to the U.S. with the mission to track down Jake Gabriel, a soldier afflicted with a virus that transforms humans into werewolves. Unbeknownst to Jack, three women in his squad have also contracted the virus and have already become she-wolves. As the malevolent she-wolves clash with Ford’s virtuous special ops team, both sides are locked in a battle to prevent humanity from succumbing to the werewolf curse.