“Bert and Arnie’s Guide to Friendship” chronicles the comedic and romantic escapades of Bert Sheering, a refined but sexually inhibited writer, and Arnie Hubert, a confident executive known for his womanizing ways. The story kicks off when Bert finds out that Arnie is having an affair with his wife, setting the stage for an unexpected adventure that blends humor, romance, and the development of an unlikely friendship. The screenplay is penned by Sal Irizarry.