A string of gruesome murders has been occurring, with each victim being a couple arranged in strange collage-like scenes, accompanied by cardboard figures and childlike notes about love’s corrupting influence. The murderer remains at large, and the FBI is on the hunt for a truck driver. Emery Reed, a long-distance trucker, has become disenchanted with the American Dream after a tragic accident left his wife paralyzed and claimed the life of their son. Meanwhile, newlyweds Jeff and Krissy are enjoying their honeymoon phase until their car breaks down on a desolate road. When their paths cross with the disheartened truck driver, an unexpected journey ensues, prompting everyone to reevaluate the true essence of love and the concept of American Romance.